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Their reciprocal relationships with nature permeated every aspect of life from spirituality to making a living and led to a different way of seeing the world, what they might call a more "environmental ... However, this changed as Native Americans shared their knowledge of how to use nature's medicines with the new settlers. While there were hundreds of herbs and plants used in Native American remedies , one of the most sacred was tobacco , which was used healing numerous conditions, as well as in rituals and ceremonies. 4.